Richard Tedder has a joint appointment with the HPA, the NHS Blood and Transplant Service (NHSBT) and UCL. The Blood Borne Virus Unit is engaged in research and development on Hepatitis Viruses and works closely with the Seromolecular Services Unit (SSU) and the NHSBT.

Clinical scientists:

Siew Lin Ngui  (siewlin.ngui@hpa.org.uk) 020 8327 6555
Samreen Ijaz  (samreen.ijaz@hpa.org.uk) 020 8327 6554
Simon Carne (simon.carne@hpa.org.uk) 0208 327 6971

NHSBT secondment: Kate Tettmar (kate.tettmar@hpa.org.uk)

Biomedical scientists:

Ruth Parry (ruth.parry@hpa.org.uk) 020 8327 6202

Healthcare scientists:

Shoshanna May  (Shoshanna.may@hpa.org.uk) 020 8327 6234

Renata Szypulska (Renata.Szypulska@hpa.org.uk) 020 8327 6234

Reference services available:

• HAV RNA detection and phylogenetics from plasma
• Hepatitis B (HBV) sequencing and phylogenetics
• HBV antiviral resistance testing
• Screening for HBsAg mutation
• Screening for pre-core & BCP mutation
• Hepatitis C (HCV) sequencing and phylogenetics
• Real time HDV RNA detection
• Real time HEV RNA assay
• HEV RNA detection and phylogenetics from plasma

S10 HBV sequencing request form (PDF, 376 KB).  

• Outbreak/transimission event investigation for HAV, HBV, HCV and HEV

For all other hepatitis virus investigations please contact:
Mr Nigel Wallis
Tel: 020 8327 6971
SSU main office: 020 8327 7262
S1 Hepatitis viruses investigation form (PDF, 408 KB).

Further details of samples required - please contact Seromolecular Services Unit (SSU)

Our diagnostic development activities include:

• Real time HAV RNA assay
• HBsAg Quantification - available on request
• Anti-HBc avidity testing - available on request
• HBeAg Quantification
• HCV antigen testing
• HDV genotyping.

Our Surveillance activities include:

• Sequencing of acute HAV cases
• Sequencing of acute HBV cases
• Enhanced surveillance of acute HBV (project SHBVACU)
  Enhanced surveillance of acute hepatitis B (PDF, 54 KB) 
• For more information please contact Samreen Ijaz
• Sequencing of HCV sero-converters
• Enhanced surveillance of HEV (project SHEV)
  Project SHEV  S7 Hepatitis E virus serology & RNA form (PDF, 379 KB)
  For more information please contact Samreen Ijaz
• HBV sequence database, HepSEQ (www.hepseqresearch.org)
  Recommended protocol for HBV genotyping and for antiviral resistance analysis (PDF, 33 KB)
  S10 HBV sequencing request form (PDF, 376 KB)
  For more information please contact Samreen Ijaz.

Our Research activities include:

• Epitope mapping of HBsAg variants including vaccine escape variants
• In vitro complementation of HBsAg
• PhD studentship on in vitro HBV phenotyping
• Blood safety studies in collaboration with NHSBT.

Recent publications

For further details of recent publications of members of the Blood Borne Virus Unit

Useful links

Hepseq  www.hepseqresearch.org
NICE  www.nice.org.uk
NHSBT www.nhsbt.nhs.uk
BASL www.basl.org.uk
SoGAT www.nibsc.ac.uk/partners/SoGAT/index.html

 

• S10 HBV sequencing request form (PDF, 376 KB)
  HBV sequencing request form, December 2010
  Added/updated: 20 December 2010
  
• BBVU Publications
  BBVU Publications 2007 - 2009 on Hepatitis viruses B, C and E.
  Added/updated: 6 October 2009
  
• Enhanced surveillance of acute hepatitis B (PDF, 54 KB)
  Enhanced surveillance of acute infection has been established in the HPA to inform and monitor the UK vaccine policy for hepatitis B, information on transmission of hepatitis B in the UK.
  Added/updated: 18 May 2011