Unit Head: Currently vacant
Technical Manager and Appendix study: Dr Reza Dabaghian
Tel: 020 8237 6503
Fax: 020 8200 1569
The TSE Unit, through the National Anonymous Tissue Archive, is involved with projects investigating the prevalence of vCJD in the British population. This work is supported by translational research aimed at developing more sensitive and specific tests for the detection of the abnormal prion protein responsible for vCJD.
The Unit is also interested in the discovery and characterisation of unrecognised and novel viruses, especially those that may be responsible for encephalitis of unknown aetiology.
The transmissible spongiform encephalopathies (TSE) are a class of diseases characterised by the appearance of a misshapen form of a normal cellular protein, known as the prion protein or PrPC. The misshapen form of this prion protein is called PrPSc or PrPTSE or PrPCJD.
TSE diseases include Creutzfeldt-Jakob disease (CJD) of humans, bovine spongiform encephalopathy of cattle and scrapie of sheep. The TSE Unit manages the laboratory aspects of the National Anonymous Tissue Archive.