Publication date: March 2012
The Clostridium difficile Ribotyping Network (CDRN) for England and Northern Ireland has continued o expand and respond to a major public health need, by providing a molecular epidemiological service hat enhances our understanding of this pathogen. Since the introduction of CDRN the reports of C. dfficile in England have fallen markedly. Reports of deaths associated with CDI have also been ecreasing since a peak in 2007. It is not possible to determine which interventions have been articularly responsible for this decreased incidence of CDI. However, it is plausible that better access to the ribotyping and enhanced fingerprinting results provided by CDRN may have facilitated better local
investigation and control of CDI cases. It is most notable that the epidemic ribotype C. difficile 027, which is associated with poor outcome, has declined markedly.
Samples are submitted to CDRN according to local clinical need. We aim to provide results within two weeks of sample receipt. We believe that the timely data provided by CDRN has enabled healthcare institutions to respond to changes in CDI presentation and/or incidence. We encourage all hospitals to consider submitting samples according to the CDRN criteria so that they can be best placed to continue to prevent and control CDI.
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Last reviewed: 29 March 2012