Locations of DNA Damage Response and Repair Genes in the Mouse and Correlation with Cancer Risk Modifiers

Summary:

The material made available here was originally published by NRPB in October 2004 as a single document in PDF format with the ISBN 0-85951-544-3.

This was been revised and reissued by HPA in September 2005 as a suite of PDF files, listed below, which include a number of active links to material external to the HPA website. The original ISBN has been withdrawn; the ISBN now applicable is cited below.

Subsequent revisions have been made in December 2005.

Users should be aware that the copyright of the material cited is not held by HPA.

Any enquiries about this document should be addressed in the first instance to dna.repair@hpa.org.uk.

An abstract is given below. A non-technical summary is also available.

Price:

Author(s):

R A Bulman, S D Bouffler, R Cox and T A Dragani

n/a

ISBN 0-85951-563-X

PDF download:

"Background, sources of loci listed in the database and outline of major DNA repair mechanisms" (PDF, 822 KB) 17 pages

Tabulation of loci of genes for DNA repair, apoptosis, cell cycle, signal transduction and mouse cancer modifier loci is given for the following chromosomes.

Chromosome 1 (PDF, 132 KB)

Chromosome 2 (PDF, 143 KB)

Chromosome 3 (PDF, 37 KB)

Chromosome 4 (PDF, 151 KB)

Chromosome 5 (PDF, 160 KB)

Chromosome 6 (PDF, 133 KB)

Chromosome 7 (PDF, 138 KB)

Chromosome 8 (PDF, 113 KB)

Chromosome 9 (PDF, 132 KB)

Chromosome 10 (PDF, 86 KB)

Chromosome 11 (PDF, 160 KB)

Chromosome 12 (PDF, 100 KB)

Chromosome 13 (PDF, 85 KB)

Chromosome 14 (PDF, 87 KB)

Chromosome 15 (PDF, 68 KB)

Chromosome 16 (PDF, 83 KB)

Chromosome 17 (PDF, 136 KB)

Chromosome 18 (PDF, 112 KB)

Chromosome 19 (PDF, 114 KB)

Chromosome X (PDF, 49 KB)

References

Abstract

Cellular DNA is subjected to continual attack by both endogenous damage from free radicals and exogenous agents such as ionising radiation, UV from sunlight, tobacco smoke and other chemical mutagens. The integrity of genomic DNA is maintained by a complex network of genome stability pathways (Wood et al, 2001).

The extensive list of human DNA repair genes assembled by Wood et al has served as the basis of this database on chromosomal location of DNA repair genes in the mouse. The growing evidence that a large proportion of apparently non-hereditary sporadic cancers occur in genetically predisposed individuals has emphasised a need to identify the underlying susceptibility genes. Increasingly, it has become evident that these genes must be identified and their chromosomal loci mapped in the mouse prior to translation to the human situation (Demant, 2003). Accordingly, the database incorporates mouse cancer modifier loci (Dragani et al, 2003). Therefore, with this database, the relationships between cancer risk modifiers and DNA damage processing genes can be explored. The database is supported by a large number of references. A small number of references on links between DNA repair, chromosomal fragile sites and chemically-induced DNA damage is also included.

The database contains links to others curated by the National Centre for Biotechology Information ( www.ncbi.nlm.nih.gov [outside link]). In addition there are diagrams of pathways of base excision repair, nucleotide excision repair, mismatch repair, non-homlogous end joining repair and homologous recombinational repair.

References

Demant, P (2003). Cancer susceptibility in the mouse: genetics, biology and implications for human cancer. Nat Rev Genet, September, 4(9), 721-34.

www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12951573 [outside link]

Dragani, TA (2003). 10 Years of mouse cancer modifier loci: human relevance. Cancer Research, 63, 3011-18.
cancerres.aacrjournals.org/cgi/content/full/63/12/3011 [outside link]

Wood, RD, Mitchell, M, Sgouros J and Lindahl, T (2001). Human DNA repair genes. Science, 291, No. 5507, 1284-9.
www.sciencemag.org/cgi/content/full/291/5507/1284 [outside link]

Last reviewed: 22 September 2009