Trypanosomiasis is an infection caused by the protozoan parasite Trypanosoma. There are two clinically significant species that infect humans: Trypanosoma cruzi, causing American trypanosomiasis or Chagas disease, which is transmitted by triatomine (kissing) bugs, and Trypanosoma brucei, causing African trypanosomiasis or sleeping sickness, which is transmitted by tsetse flies.